Oxford's long delayed PRINCIPLE trial just set a new record for ivermectin research fraud when they silently published it as a negative study despite their data showing profoundly positive impacts.
Great article. I was reading the paper itself and I noticed the pre-specified hazard ratio to be "clinically meaningful" is 1.2, not 2.0 as you put in this article. Otherwise everything looks good
I am following the trial of Dr. Hoffe the courageous doctor from Vancouver, who is being persecuted by his regulatory body. In the biased article about him they cite the most recent research about ivermectin claiming it is in effective. I would like Dr. Kory’s take on the I-TECH RANDOMIZED CLINICAL TRIAL.STEVEN Chee Loon Lim is the lead author. Of course this trial states that ivermectin is ineffective. I am currently in a battle with the college of nurses of Ontario, trying to defend myself for having used ivermectin for many patients with great effect. The great affect doesn’t matter though.
In case you are not aware, the major appendix to the paper - with much of the positive data you cite - seems to have been deleted from the journal site. Instead they have duplicated a minor appendix, presumably so it still looks like there are 2 appendices.
Dr. Kory is a force! This MR. Butler doesn't even know basic science principles in research! If I had written a summary like this, or designed this study, in my clinical chemistry class for medical technology my instructor would have failed me - and rightly so. Oxford should be embarrassed and ashamed, what an insult to human intelligence - the new narrative these days.
This bastardizing of medical research and our profession brought to mind the recent study on vitamin D supplementation published in the NEJM ( the VITAL study). I'm currently in a controversy over whether our "group" should pursue identification and correction of vitamin D deficiency in our patient population. In my frustration, I mused about a comparable study we could do to disparage treatment of hypertension, were we so inclined. See below:
Amlodipine Supplementation IN Individuals NEeding treatment for hypertension (known as the ASININE trial) by I.C. Little, et. al.**
Abstract: We identified 10,181 patient volunteers diagnosed with essential hypertension based on use of ambulatory blood pressure monitoring (ABPM) for 30 days or more. During a 1 month washout period enrollees were supplemented with Amlodipine 1 mg PO daily and those without significant side effects were continued in the trial (N=9832) and followed for a period of 5 years. Any Major Adverse Cardiovascular Events (MACE) were documented, and comparisons made to a matched control group of 6892 persons without hypertension based on CBPM. Post hoc analysis failed to identify any statistically significant reduction in MACE with use of Amlodipine. Based on the *IRSOWWW approach developed by big pharma we conclude that there is no clinical value to the use of Amlodipine in patients with hypertension.
*IRSOWWW (Inductive Reasoning to See Only What We Want)
**In the interest of space, financial conflicts of interest are listed on pages 102-149
No words can express gratitude to what you have done during Pandemic and keep doing Dr. Kory. I have many heroes in Freedom movement, but you are undoubtedly my number one guy!
Dr. Kory. A couple things: first, i would like you to know how much so manybof us appreciate your courage and diligence and persistence.
2nd, i would like to advocate for a different pay structure in substack so that writers like yourself can get better compensated. Netflix used to charge $9.99/mo. This supported hundreds of movie staff (cast and crew and writers and producers etc). Newspapers often charge $2/mo for a subscription for their dozens of staff. But substack has a 5 or 6 dollar minimum for ONE writer who may or may not produce daily or weekly or monthly articles. I have at least 20 writers i would love to support. I was trying to for more than a year. But with 5 kids it nearly breaks the bank. Why can't they do $9/mo for like 20 writers/substacks? I think exponentially more people would subscribe and thus many more writers would get the revenue they deserve and many more people would be better informed. They MUST come up with a better revenue sharing plan if they want to keep engaged writers and grow their paying base. Please advocate to substack.
1) Matrix Metalloproteinase (MMP) Inhibition: Doxycycline inhibits MMPs which play a role in tissue remodeling, and can facilitate tumor invasion and metastasis.
2) Inhibition of Cell Proliferation: Doxycycline has been shown to inhibit the proliferation of various cancer cell lines.
3) Induction of Apoptosis: Doxycycline can induce apoptosis or programmed cell death in cancer cells.
4) Mitochondrial Disruption: Doxycycline affects the mitochondrial function in cancer cells leading to reduced cancer cell viability.
5) Inhibition of Angiogenesis: Angiogenesis is the process by which new blood vessels form. Tumors require these vessels to grow. Doxycycline has anti-angiogenic properties, thus preventing tumor growth.
6) Stem Cell Modulation: Doxycycline can target cancer stem cells, preventing tumor initiation, metastasis, and resistance to therapy.
7) Reduction in Tumor Growth: In animal models, Doxycycline has been shown to reduce tumor size.
8) Enhancement of Chemotherapeutic Effects: In some studies, Doxycycline has been shown to enhance the effects of traditional chemotherapeutic agents.
9) Inhibition of Epithelial-to-Mesenchymal Transition (EMT): EMT is a process by which cancer cells gain migratory and invasive properties. Doxycycline has been shown to inhibit this process.
10) Autophagy Modulation: Autophagy is a cellular mechanism that can sometimes aid cancer cell survival through the process of reusing damaged and old cell parts. Doxycycline has been found to modulate this process in cancer cells, downregulating the cancer cells’ ability to repair.
11 Immune Modulation: Some research suggests Doxycycline can modulate the tumor microenvironment, potentially positively impacting the immune response to tumors.
12) Targeting Microbial Influence: There's an evolving understanding of the role of microbes in cancer progression. Given its antibiotic properties, Doxycycline might influence the tumor-associated microbiome and thereby enhance anticancer response.
1. Matrix Metalloproteinase (MMP) Inhibition:
Tetracyclines inhibit connective tissue breakdown by multiple non-antimicrobial mechanisms - Golub LM, et al.
I was aware of ivermectin only after watching your senate testmony. In August 2021 I had shortness of breath and flu like symptoms and got an online presciption for ivermectin and fluvoamine. I took my first deep breath in two weeks four hours after taking the ivermectin . Thank you.
We used 10-15mg of diazepam, kept in a safe, only used at time of physical medicine/therapy , for Patients that could not tolerate the pain of what We.needed to do. Patients were put in an exam room for +- 3 hours S/P then safely transported home. Ed
It was published by My Friend/Physician He was one of those that only needed 4 hours of sleep😂. Although My Idea, Medical Hypothesis or some such publication. I can’t remember exactly. I did not care…I was too busy keeping track of Patients that needed help. 🔥
Great article. I was reading the paper itself and I noticed the pre-specified hazard ratio to be "clinically meaningful" is 1.2, not 2.0 as you put in this article. Otherwise everything looks good
I am following the trial of Dr. Hoffe the courageous doctor from Vancouver, who is being persecuted by his regulatory body. In the biased article about him they cite the most recent research about ivermectin claiming it is in effective. I would like Dr. Kory’s take on the I-TECH RANDOMIZED CLINICAL TRIAL.STEVEN Chee Loon Lim is the lead author. Of course this trial states that ivermectin is ineffective. I am currently in a battle with the college of nurses of Ontario, trying to defend myself for having used ivermectin for many patients with great effect. The great affect doesn’t matter though.
Cannot find the critique of the NEJM (Reis) study. Any link?
In case you are not aware, the major appendix to the paper - with much of the positive data you cite - seems to have been deleted from the journal site. Instead they have duplicated a minor appendix, presumably so it still looks like there are 2 appendices.
https://www.sciencedirect.com/science/article/pii/S0163445324000641#sec0140
I'm sure you grabbed a copy before they did this, but let me know if not, I have one.
Dr. Kory is a force! This MR. Butler doesn't even know basic science principles in research! If I had written a summary like this, or designed this study, in my clinical chemistry class for medical technology my instructor would have failed me - and rightly so. Oxford should be embarrassed and ashamed, what an insult to human intelligence - the new narrative these days.
In Medicine, One of My favorite sayings was, “Free Your Mind”. It was printed on
T-Shirts. Ed
Dr. Kory, in the report, what was the ivermectin source that was shown to be lower in efficacy? I’d like to know I’m not using that source!
This bastardizing of medical research and our profession brought to mind the recent study on vitamin D supplementation published in the NEJM ( the VITAL study). I'm currently in a controversy over whether our "group" should pursue identification and correction of vitamin D deficiency in our patient population. In my frustration, I mused about a comparable study we could do to disparage treatment of hypertension, were we so inclined. See below:
Amlodipine Supplementation IN Individuals NEeding treatment for hypertension (known as the ASININE trial) by I.C. Little, et. al.**
Abstract: We identified 10,181 patient volunteers diagnosed with essential hypertension based on use of ambulatory blood pressure monitoring (ABPM) for 30 days or more. During a 1 month washout period enrollees were supplemented with Amlodipine 1 mg PO daily and those without significant side effects were continued in the trial (N=9832) and followed for a period of 5 years. Any Major Adverse Cardiovascular Events (MACE) were documented, and comparisons made to a matched control group of 6892 persons without hypertension based on CBPM. Post hoc analysis failed to identify any statistically significant reduction in MACE with use of Amlodipine. Based on the *IRSOWWW approach developed by big pharma we conclude that there is no clinical value to the use of Amlodipine in patients with hypertension.
*IRSOWWW (Inductive Reasoning to See Only What We Want)
**In the interest of space, financial conflicts of interest are listed on pages 102-149
I am so sorry that so many people will believe this. https://drcolinbannon.substack.com/p/the-real-scandal-of-ivermectin?utm_source=%2Fsearch%2Fivermectin&utm_medium=reader2
They only work at “the speed of science” when the speed can harm you.
No words can express gratitude to what you have done during Pandemic and keep doing Dr. Kory. I have many heroes in Freedom movement, but you are undoubtedly my number one guy!
Dr. Kory. A couple things: first, i would like you to know how much so manybof us appreciate your courage and diligence and persistence.
2nd, i would like to advocate for a different pay structure in substack so that writers like yourself can get better compensated. Netflix used to charge $9.99/mo. This supported hundreds of movie staff (cast and crew and writers and producers etc). Newspapers often charge $2/mo for a subscription for their dozens of staff. But substack has a 5 or 6 dollar minimum for ONE writer who may or may not produce daily or weekly or monthly articles. I have at least 20 writers i would love to support. I was trying to for more than a year. But with 5 kids it nearly breaks the bank. Why can't they do $9/mo for like 20 writers/substacks? I think exponentially more people would subscribe and thus many more writers would get the revenue they deserve and many more people would be better informed. They MUST come up with a better revenue sharing plan if they want to keep engaged writers and grow their paying base. Please advocate to substack.
1) Matrix Metalloproteinase (MMP) Inhibition: Doxycycline inhibits MMPs which play a role in tissue remodeling, and can facilitate tumor invasion and metastasis.
2) Inhibition of Cell Proliferation: Doxycycline has been shown to inhibit the proliferation of various cancer cell lines.
3) Induction of Apoptosis: Doxycycline can induce apoptosis or programmed cell death in cancer cells.
4) Mitochondrial Disruption: Doxycycline affects the mitochondrial function in cancer cells leading to reduced cancer cell viability.
5) Inhibition of Angiogenesis: Angiogenesis is the process by which new blood vessels form. Tumors require these vessels to grow. Doxycycline has anti-angiogenic properties, thus preventing tumor growth.
6) Stem Cell Modulation: Doxycycline can target cancer stem cells, preventing tumor initiation, metastasis, and resistance to therapy.
7) Reduction in Tumor Growth: In animal models, Doxycycline has been shown to reduce tumor size.
8) Enhancement of Chemotherapeutic Effects: In some studies, Doxycycline has been shown to enhance the effects of traditional chemotherapeutic agents.
9) Inhibition of Epithelial-to-Mesenchymal Transition (EMT): EMT is a process by which cancer cells gain migratory and invasive properties. Doxycycline has been shown to inhibit this process.
10) Autophagy Modulation: Autophagy is a cellular mechanism that can sometimes aid cancer cell survival through the process of reusing damaged and old cell parts. Doxycycline has been found to modulate this process in cancer cells, downregulating the cancer cells’ ability to repair.
11 Immune Modulation: Some research suggests Doxycycline can modulate the tumor microenvironment, potentially positively impacting the immune response to tumors.
12) Targeting Microbial Influence: There's an evolving understanding of the role of microbes in cancer progression. Given its antibiotic properties, Doxycycline might influence the tumor-associated microbiome and thereby enhance anticancer response.
1. Matrix Metalloproteinase (MMP) Inhibition:
Tetracyclines inhibit connective tissue breakdown by multiple non-antimicrobial mechanisms - Golub LM, et al.
Doxycycline is a tetracycline-class antibiotic.
Brilliant. Well done. Thank you for this.😊
If I sent a link to this report to a non-subscriber, would they be able to read it?
I was aware of ivermectin only after watching your senate testmony. In August 2021 I had shortness of breath and flu like symptoms and got an online presciption for ivermectin and fluvoamine. I took my first deep breath in two weeks four hours after taking the ivermectin . Thank you.
We used 10-15mg of diazepam, kept in a safe, only used at time of physical medicine/therapy , for Patients that could not tolerate the pain of what We.needed to do. Patients were put in an exam room for +- 3 hours S/P then safely transported home. Ed
It was published by My Friend/Physician He was one of those that only needed 4 hours of sleep😂. Although My Idea, Medical Hypothesis or some such publication. I can’t remember exactly. I did not care…I was too busy keeping track of Patients that needed help. 🔥